![]() The high-increasing trajectory of the TyG index tended to be associated with CAS progression (HR = 1.206, 95% CI 0.961–1.513). After multivariate adjustment, the moderate-stable group had a 1.139-fold (95% CI 1.021–1.272) risk of CAS progression. ![]() According to different trajectory patterns, participants were categorized into low-stable, moderate-stable, and high-increasing groups. Similar results were observed when the TyG index was expressed as quartiles. Each 1-standard deviation (SD) increase in the TyG index was associated with a 7% higher risk of CAS progression after adjusting for traditional CVD risk factors (HR = 1.067, 95% CI 1.006–1.132). Resultsĭuring a median follow-up period of 757 days, 1813 participants developed CAS progression. Based on univariate and multivariate Cox proportional hazards analyses, hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated for the baseline and trajectory of the TyG index. The latent class trajectory modeling method was used to analyze the TyG index trajectories over the follow-up. The TyG index was calculated as ln (fasting triglyceride × fasting glucose /2). This longitudinal prospective cohort study included 10,380 adults with multiple general health checks at Peking University Third Hospital from January 2011 to December 2020. However, the prospective relationship between baseline and long-term trajectories of the TyG index and carotid atherosclerosis (CAS) progression has yet to be investigated. The triglyceride-glucose (TyG) index has been recognized as being an alternative cardiometabolic biomarker for insulin resistance associated with the development and prognosis of cardiovascular disease (CVD).
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